I've stayed at Ayre Hotels before and the service, comfort, and everything has always been top quality. The Madrid hotel was no exception in terms of decor, comfort and location; however, it lacked some basic components that made the stay less great than I've had before.
One night I cut my firnger and was bleeding non-stop. I went down to reception to ask for band-aids and they said they didn't have a first aid kit! I had to walk to the other reception to get some help. The next day I asked for another band aid and they said they ran out. I ran to the first "AlimentaciÃ³n" store to buy some. Ridiculous.
Overall excellent staff, very good stay, but every hotel needs to have the basics down, and the Ayre did not.